In his true freshman year in 2011, Collins played in seven games with no starts. In a total of 46 snaps on the offensive line, he posted five knockdown blocks and was recognized as a Freshman All-American by CBSSports.com after the season. As a sophomore, Collins started all 13 games for LSU, replacing Will Blackwell at left guard, and led the team in both total snaps (836) and knockdowns (64.5). He was named SEC Offensive Lineman of the Week after playing all 84 offensive snaps at #1 Alabama, helping the Tigers to compile 22 first downs, 139 yards rushing, and 296 passing against the nation’s No. 1 defense. Having played every offensive snap in LSU’s last eleven games, Collins earned honorable mention All-SEC honors by the Associated Press.
In his junior season, Collins was moved to left tackle, filling the void left by Chris Faulk. Quickly adjusting to his new position, he earned SEC Offensive Lineman of the Week honors after playing all but one snap in a 37–27 over Texas Christian in the season-opener. Collins went on the start twelve games at left tackle, only missing the Furman game in October. Louisiana State’s offense accounted for school-record 465.9 total yards per game, which included 200.8 rushing and 256.8 passing, and a school-record 37 rushing touchdowns.
Collins turned down an opportunity to enter the 2014 NFL Draft to return to LSU for his senior season. He started all 13 games at left tackle, leading the team in both offensive snaps (843) and knockdowns (88). The Tigers offense rushed for an average of 224.5 yards a game, the most by the team since averaging 256.6 in 1997. After the season, Collins was awarded the Jacobs Blocking Trophy, given annually to the top offensive lineman in the SEC as voted on by the league’s coaches, as the first LSU Tiger to win since Ciron Black in 2009. Collins was also voted First-team All-SEC by the league’s coaches and the Associated Press. Both USA Today and AP named him second team All-American.